SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Amendment No. 1)

Under the Securities Exchange Act of 1934

The Medicines Company

(Name of Issuer)

Common Stock, $0.001 par value

(Title of Class of Securities)

584688105

(CUSIP Number)

December 31, 2006

(Date of Event Which Requires Filing of this Statement)

Check the following box to designate the rule pursuant to which the Schedule is filed:

o	Rule 13d-1(b)
x	Rule 13d-1(c)
o	Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 584688105
	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) D. E. Shaw & Co., L.P. 13-3695715

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o

	3.	SEC Use Only

	4.	Citizenship or Place of Organization Delaware

Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power -0-

			6.		Shared Voting Power 2,241,491

			7.		Sole Dispositive Power -0-

			8.		Shared Dispositive Power 2,241,491

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 2,241,491

	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o

	11.	Percent of Class Represented by Amount in Row (9) 4.4%

	12.	Type of Reporting Person (See Instructions) IA, PN

CUSIP No. 584688105

	1.	Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) David E. Shaw

	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o

	3.	SEC Use Only

	4.	Citizenship or Place of Organization United States

Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power -0-

			6.		Shared Voting Power 2,241,491

			7.		Sole Dispositive Power -0-

			8.		Shared Dispositive Power 2,241,491

	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 2,241,491

	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o

	11.	Percent of Class Represented by Amount in Row (9) 4.4%

	12.	Type of Reporting Person (See Instructions) IN

Item 1.
(a)		Name of Issuer
		The Medicines Company

(b)		Address of Issuer's Principal Executive Offices
		8 Campus Drive Parsippany, NJ 07054

Item 2.
(a)		Name of Person Filing
		D. E. Shaw & Co., L.P. David E. Shaw

(b)		Address of Principal Business Office or, if none, Residence
		The business address for each reporting person is: 120 W. 45^th Street, Tower 45, 39^th Floor New York, NY 10036

(c)		Citizenship
		D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America.

(d)		Title of Class of Securities
		Common Stock, $0.001 par value

(e)		CUSIP Number
		584688105

Item 3.		If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:

Not applicable

Item 4.

Ownership

As of December 31, 2006:

(a) Amount beneficially owned:

D. E. Shaw & Co., L.P.:	2,241,491 shares This is composed of (i) 2,050,000 shares in the name of D. E. Shaw Meniscus Portfolios, L.L.C., (ii) 311 shares in the name of D. E. Shaw Synoptic Portfolios 2, L.L.C., (iii) 141,680 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., and (iv) 49,500 shares that D. E. Shaw Valence, L.L.C. has the right to acquire through the exercise of listed call options.
David E. Shaw:	2,241,491 shares This is composed of (i) 2,050,000 shares in the name of D. E. Shaw Meniscus Portfolios, L.L.C., (ii) 311 shares in the name of D. E. Shaw Synoptic Portfolios 2, L.L.C., (iii) 141,680 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., and (iv) 49,500 shares that D. E. Shaw Valence, L.L.C. has the right to acquire through the exercise of listed call options.

(b) Percent of class:

	D. E. Shaw & Co., L.P.:	4.4%
	David E. Shaw:	4.4%

(i) Sole power to vote or to direct the vote:

	D. E. Shaw & Co., L.P.:	-0- shares
	David E. Shaw:	-0- shares

(ii) Shared power to vote or to direct the vote:

	D. E. Shaw & Co., L.P.:	2,241,491 shares
	David E. Shaw:	2,241,491 shares

(iii) Sole power to dispose or to direct the disposition of:

	D. E. Shaw & Co., L.P.:	-0- shares
	David E. Shaw:	-0- shares

(iv) Shared power to dispose or to direct the disposition of:

	D. E. Shaw & Co., L.P.:	2,241,491 shares
	David E. Shaw:	2,241,491 shares

David E. Shaw does not own any shares directly. By virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Meniscus Portfolios, L.L.C. and D. E. Shaw Synoptic Portfolios 2, L.L.C., the managing member and investment adviser of D. E. Shaw Valence Portfolios, L.L.C., and the managing member of D. E. Shaw Valence, L.L.C., and by virtue of David E. Shaw’s position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the managing member of D. E. Shaw Meniscus Portfolios, L.L.C. and D. E. Shaw Synoptic Portfolios 2, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of, and the shared power to dispose or direct the disposition of, the 2,241,491 shares as described above constituting 4.4% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 2,241,491 shares.

Item 5.		Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following x

Item 6.		Ownership of More than Five Percent on Behalf of Another Person.
Not Applicable

Item 7.		Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.
Not Applicable

Item 8.		Identification and Classification of Members of the Group
Not Applicable

Item 9.		Notice of Dissolution of Group
Not Applicable

Item 10.	Certification

By signing below, each of D. E. Shaw & Co., L.P. and David E. Shaw certify that, to the best of such reporting person’s knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purposes or effect.

SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. A Power of Attorney, dated February 24, 2004, granted by David E. Shaw in favor of Anne Dinning, is attached hereto.

Dated: February 14, 2007


	D. E. Shaw & Co., L.P.

	By:	/s/ Anne Dinning
		Anne Dinning Managing Director



	David E. Shaw

	By:	/s/ Anne Dinning
		Anne Dinning Attorney-in-Fact for David E. Shaw